Monoclonal Antibodies: Theory And Production
Monoclonal Antibodies: Theory and Production (9848-10)
Review the topic of monoclonal antibodies and the differences between polyclonal and monoclonal antibodies. By the end of this module the student should have a good understanding of the fundamentals of monoclonal antibodies in laboratory medicine and as their potential of treating a wide range of serious diseases.
PEP hours: 14
CPS/ART credits: 0.6
Course Type: Express
Start Date: Upon registration
Completion: Up to 52 weeks
Delivery: PDF via email
Equipment: Computer with Internet is required
- Review the nature of antigens, antibodies and immunogenicity
- Describe the structure and nature of antibodies
- Draw the relevant parts of a plasma cell
- Describe the principles of cell fusion and hybridoma production.
- Outline the method of monoclonal antibody production.
- Tabulate the advantages and disadvantages of monoclonal antibodies.
- Describe briefly the principles behind chimeric and humanized monoclonal antibodies
- Outline how monoclonal antibodies are purified
- Describe the terminology for naming monoclonal antibodies as set out by USANC
- Describe the role transgenic mice play in monoclonal antibody preparation
- Explain the principles of antigen
Author/Instructor: John Chapman, FCSMLS, FIMLS, CLSp(H)
Version Date: September 2010