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Macrocytic Anemias

 Macrocytic Anemias (9801-10) Learn more about the macrocytic anemias with emphasis on the megaloblastic anemias. Classification, etiology and characteristic laboratory findings are examined in relation to differentiation of non-megaloblastic from megaloblastic anemia. Version Date: April 2010

Code 9801-10
Level Basic

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Additional Details

PEP hours: 9
CPS credits: 0
Level: Basic
Course Type: Express

Start Date: Upon registration
Completion: Up to 52 weeks
Delivery: PDF via email

Prerequisites: None
Textbook: N/A
Equipment: Computer with Internet is required

Learning Outcomes:

  • Classify the macrocytic anemias into two major groups
  • Write a definition for megaloblastic anemia
  • Briefly describe the metabolism and functions of vitamin B12 and folic acid
  • State the underlying cause of all types of megaloblastic anemias
  • Describe the specific causes (3) of the anemia in megaloblastic anemias
  • Name the two major types of megaloblastic anemia
  • List and discuss typical laboratory findings in a megaloblastic anemia
  • Differentiate (morphologically) a megaloblast from a normoblast (erythroblast)
  • Name the cell stages of the megaloblastic erythroid series
  • List several causes of vitamin B12 deficiency
  • Write a definition of pernicious anemia and discuss its specific etiology including the production and role of intrinsic factor and the types of autoantibodies
  • List several lab tests to identify: vitamin B12 deficiency anemia; abnormal vitamin B12 absorption; pernicious anemia
  • Briefly define folic acid deficiency anemia, including its major causes, and list the most important laboratory test for its diagnosis
  • Briefly describe some disorders that show bone marrow megaloblasts but which fail to respond to therapy with vitamin B12 or folate
  • List the three major categories of non-megaloblastic macrocytic anemias and some specific causes
  • List lab findings which differentiate non-megaloblastic anemias from megaloblastic anemias

Author/Instructor: Bill McTaggart, BSc, ART
Version Date: April 2010