Introduction To Platelet Structure And Function
Introduction To Platelet Structure And Function (9817-10)
Learn about platelet production, kinetics and regulation, aggregation and understand the effect of drugs on platelets. Platelet factors and the arachidonic acid-prostacyclin pathways are also discussed.
PEP hours: 11
CPS/ART credits: 0.7
- Describe the production of platelets in the body including platelet kinetics, life span and regulation.
- Describe in detail, and draw the ultrastructure of a typical platelet.
- Outline the relationships between the different structural zones of the platelet.
- Describe the current understanding of the regulatory protein thrombopoietin.
- Briefly describe the formation of a platelet hemostatic plug.
- Give a detailed review of the platelet interaction with the vessel wall.
- Describe the process of aggregation and list the agents that initiate it.
- List many of the substances available over the counter that contains aspirin.
- Outline the logic for daily aspirin therapy.
- Describe the agents that inhibit platelet aggregation.
- Prepare a list of drugs that have an affect on platelet function
- Outline the specific features of PF3 and PF4.
- Describe schematically the arachidonic acid - prostacyclin pathways.
- List the compounds released from platelets upon activation.
- Describe the effect of ethanol on platelets.
Instructor: John Chapman, FCSMLS, FIMLS, CLSp(H)
Equipment: Computer with Internet is required
Start Date: Upon registration
Completion: Up to 52 weeks
Version Date: January 2010