Case Studies: Patients With Platelet Disorders - Series Two
Case Studies: Patients with Platelet Disorders - Series Two (9864-08)
Continue to increase your knowledge and problem solving skills by using five case studies to analyse HELLP syndrome, idiopathic thrombocytopenia purpura, thrombotic thrombocytopenic purpura, Von Willebrand's disease, and the hyper-responder to aspirin.
PEP hours: 16
CPS credits: 0
Course Type: Express
Start Date: Upon registration
Completion: Up to 52 weeks
Delivery: PDF via email
Prerequisites: Case Studies: Patients with Platelet Disorders - Series One (9863-08)
Equipment: Computer with Internet is required
- Discuss the laboratory options in the investigation of a patient that presents with a laboratory picture of microangiopathy.
- Outline the specific laboratory findings of the HELLP Syndrome.
- Tabulate the laboratory findings seen in thrombocytopenic disorders.
- Define the HELLP Syndrome and how it is differentiated from other similar syndromes (DIC,AFLP,TTP,HUS,ITP)
- Discuss the differences and similarities between childhood and adult immune thrombocytopenia.
- Discuss the value of testing patients for platelet antibodies.
- Review the treatment options for patients with ITP and how the laboratory status assists in making these decisions.
- Tabulate the various forms of drug therapies and their respective response rates in patients with ITP.
- Describe the clinical and laboratory findings seen in TTP.
- Discuss the role of vWF in the etiology of TTP.
- Review briefly the history of TTP and how it relates to today’s understanding of the pathophysiology.
- Outline the laboratory differences between TTP, HUS and DIC.
- Outline the specific role of vWF and ADAMTS-13 in TTP.
- Review the clinical and laboratory findings of type 1 vWD.
- Discuss the laboratory tests (coagulation, platelet function, aggregation) and their role in diagnosing vWD.
- Define the various factors involved in vWD: factor VIII, factor VIIIC, factor VIII:Ag, factor VIIIRcof, factor VIII:vWF complex and vWF.
- Tabulate the laboratory features of type 1, type 2a, type 2b and type 2c vWD.
- List the overall diagnostic features (clinical and laboratory) of the various vWD types.
- Discuss the treatment options for the most common vWD types.
- Outline the role of aspirin in defective platelet function and the identification of hyper responders.
- Briefly outline the sequence of events that take place when platelets are activated.
- Draw conceptually the arachidonic acid, cyclo-oxygenase and lipogenase pathways.
- List the manner by which the biochemical compounds formed influence platelet function.
Author/Instructor: John Chapman, FCSMLS, FIMLS, CLSp(H)
Version Date: December 2008