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Case Studies: Patients With Platelet Disorders - Series Two

 Case Studies: Patients with Platelet Disorders - Series Two (9864-14) Continue to increase your knowledge and problem solving skills by using five case studies to analyse HELLP syndrome, idiopathic thrombocytopenia purpura, thrombotic thrombocytopenic purpura, Von Willebrand's disease, and the hyper-responder to aspirin. Version Date: March 2014

Code 9864-14
Level Advanced

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Additional Details

PEP hours: 16
CPS credits: 1.0
Level: Advanced
Course Type: Express

Start Date: Upon registration
Completion: Up to 52 weeks
Delivery: PDF via email

Prerequisites: Case Studies: Patients with Platelet Disorders - Series One (9863-14)
Textbook: N/A
Equipment: Computer with Internet is required

Learning Outcomes:

  • Discuss the laboratory options in the investigation of a patient that presents with a laboratory picture of microangiopathy
  • Outline the specific laboratory findings of the HELLP Syndrome
  • Tabulate the laboratory findings seen in thrombocytopenic disorders
  • Define the HELLP Syndrome and how it is differentiated from other similar syndromes (DIC,AFLP,TTP,HUS,ITP)
  • Discuss the differences and similarities between childhood and adult immune thrombocytopenia
  • Discuss the value of testing patients for platelet antibodies
  • Review the treatment options for patients with ITP and how the laboratory status assists in making these decisions
  • Tabulate the various forms of drug therapies and their respective response rates in patients with ITP
  • Describe the clinical and laboratory findings seen in TTP
  • Discuss the role of vWF in the etiology of TTP
  • Review briefly the history of TTP and how it relates to current understanding of the pathophysiology
  • Outline the laboratory differences between TTP, HUS and DIC
  • Outline the specific role of vWF and ADAMTS-13 in TTP
  • Review the clinical and laboratory findings of type 1 vWD
  • Discuss the laboratory tests (coagulation, platelet function, aggregation) and their role in diagnosing vWD
  • Define the various factors involved in vWD: factor VIII, factor VIIIC, factor VIII:Ag, factor VIII:Rco, factor VIII:vWF complex and vWF
  • Tabulate the laboratory features of type 1, type 2a, type 2b and type 2c vWD
  • List the overall diagnostic features (clinical and laboratory) of the various vWD types
  • Discuss the treatment options for the most common vWD types
  • Outline the role of aspirin in defective platelet function and the identification of hyper responders
  • Briefly outline the sequence of events that take place when platelets are activated
  • Draw conceptually the arachidonic acid, cyclooxygenase and lipoxygenase pathways
  • List the manner by which the biochemical compounds formed influence platelet function
  • Discuss use of the bleeding time in assessing platelet function

Author/Instructor: John Chapman, FCSMLS, FIMLS, CLSp(H)
Version Date: March 2014